Structural factors and the HIV prevention and treatment cascades: where are we? - Sinead Delany-Moretlwe and James Hargreaves

There remains an unmet need for HIV prevention, particularly among key populations including adolescent girls and young women in Africa. The treatment cascade framework, and its associated 90:90:90 targets, has galvanised action to expand testing and treatment for prevention. The prevention cascade framework hopes to do the same for primary prevention, mapping the steps needed to achieve high coverage of efficacious prevention tools. Both frameworks illustrate how ART-based HIV prevention offers real promise for reducing HIV incidence at a population level. However, challenges remain.

International Women's Day: Women, HIV and PrEP

On International Women's Day, the Centre for Maternal, Adolescent, Reproductive and Child Health published an interview with STRIVE Co-Research Director, Mitzy Gafos, about HIV amongst women and the challenges they face adhering to PrEP. 

Interim Results of Open-Label Study of IPM’s Dapivirine Vaginal Ring Find Increased Product Use and Suggest Greater HIV Risk Reduction

Interim data from a large open-label study of the monthly dapivirine ring have found increased product use compared to a previous Phase III study. In addition, modeling data suggest that women’s HIV-1 risk in the study, known as DREAM, was reduced by more than half.

Developed by the nonprofit International Partnership for Microbicides (IPM), the monthly ring slowly releases the antiretroviral (ARV) drug dapivirine and is currently under regulatory review. The ring is designed to provide women with a discreet and long-acting HIV prevention option.

HIV-1 transmission networks in high risk fishing communities on the shores of Lake Victoria in Uganda: A phylogenetic and epidemiological approach

, ; Read the full paper online

Fishing communities around Lake Victoria are a population at high risk of HIV infection.

Interventions to improve antiretroviral therapy adherence among adolescents in low- and middle-income countries: A systematic review of the literature

, ; Read the full paper online

Globally, an estimated 30% of new HIV infections occur among adolescents (15–24 years), most of whom reside in sub-Saharan Africa. Moreover, HIV-related mortality increased by 50% between 2005 and 2012 for adolescents 10–19 years while it decreased by 30% for all other age groups. Efforts to achieve and maintain optimal adherence to antiretroviral therapy are essential to ensuring viral suppression, good long-term health outcomes, and survival for young people.

STRIVE for the SDGs

Join us for a free webinar on 22 March 2018, 11.30 am GMT.

Join us for a free webinar on 22 March 2018, 11.30 am GMT.

A mixed-method review of cash transfers and intimate partner violence in low and middle-income countries

, ; Read the full working paper online

There is increasing evidence that cash transfer (CT) programs decrease intimate partner violence (IPV); however, little is known about how CTs achieve this impact.

Drawing on a mixed method review of studies in low- and middle-income countries, as well as related bodies of evidence, the authors developed a program theory proposing three pathways through which CT could impact IPV:

Incorporating structural interventions in country HIV programme planning and resource allocation

Can we include structural interventions in the models that guide national investments? And if so, how?

Norms Learning Report 2: Theory in support of better practice

Discussions and lessons from a two-day expert group on using social norm and gender theories in intervention design.

Youth Perspectives on Alcohol: Availability and marketing in South Africa, Tanzania and India

Alcohol use among young people exposes them to a variety of social, economic and public health hazards and is one of the drivers of the HIV epidemic in developing countries. This Learning Lab presents findings from a STRIVE multi-country study in South Africa, Tanzania and India which assessed how alcohol availability and promotion affect young people’s sexual health and safety.

The researchers highlight shared and unique findings from the three contexts including: